First described by French scientist Dr Michel Pistor in 1952, it was approved for cosmetic applications by the FNAM organisation in 1986. Mesotherapy is in the class of minimal interventional methods. It is aimed to get rid of many negative effects on the skin with small touches. The application can be done only by micro-needling method or it can be done in the form of injection of minerals, amino acids and vitamins under the skin during needling. It can be used for skin spot treatment, rejuvenation, scar treatment, hair regeneration. Recently, it has been used in both weight loss and crack cellulite treatment. Treatment time takes about 15 minutes. The interval between sessions is approximately 3 weeks.